Alzheimer's Imaging Consortium

Saturday, July 15, 2017
8 a.m. – 5:30 p.m.
ExceL London, Hall S10-C
London, England

Overview

The Alzheimer's Imaging Consortium (AIC), a preconference to the Alzheimer's Association International Conference (AAIC), will focus on the clinical application and methodological development of neuroimaging (MRI, PET, SPECT, CT and others) to Alzheimer's disease, other dementias and normal brain aging. The program consists of invited speakers, as well as oral and poster presentations from submitted abstracts.

The AIC is organized by the Neuroimaging Professional Interest Area of the International Society to Advance Alzheimer's Research and Treatment (ISTAART).

Program Chairs

Plenary Speakers

Agenda
  • Time
  • Topics

8 - 8:30 a.m.

Opening Remarks

David Wolk, M.D.
Chair, Neuroimaging Professional Interest Area (NIPIA); University of Pennsylvania, United States

8:30 - 9 a.m.

Chair: Bradford Dickerson, Massachusetts General Hospital, United States

ICI-001
Plenary Session: What Have We Learned?
Annie Racine, Ph.D., Harvard Medical School, United States


9:00 - 10:15 a.m.

Chairs: Keith Johnson, Massachusetts General Hospital, USA
Renaud La Joie, University of California, San Francisco, United States

IC-01
IC-01-01 AV1451-PET Cortical Uptake and Regional Distribution Predicts Longitudinal Atrophy in Alzheimer’s Disease

Renaud La Joie, Adrienne Visani, Viktoriya Bourakova, Suzanne Baker, Nagehan Ayakta, Julie Pham, Ashley Mensing, Howard Rosen, Bruce Miller, William Jagust, Gil Rabinovici

IC-01-02 White Matter Integrity Reflects Tau Accumulation in AD Defined Regions
Jeremy Strain, Robert Smith, Helen Beaumont, Brian Gordon, Shruti Mishra, Jon Christensen, John Morris, Tammie Benzinger, Beau Ances

IC-01-03 Relationship Among Tau, Amyloid Burden and Brain Atrophy in the Early-Onset Alzheimer's Disease and Late-Onset Alzheimer's Disease
Young Noh, Han Kyu Na, Seongho Seo, Sang-Yoon Lee, Hye Jin Jeong, Nobuyuki Okamura, Tatsuo Ido, Duk L. Na

IC-01-04 A Robust, Simplified Braak-Type Classification Scheme for Flortaucipir F 18 Tau PET Images
Adam Schwarz, Lawrence Slieker, Shannon Risacher, Sudeepti Southekal, Abhinay Joshi, Michael Devous, Andrew Saykin

IC-01-05 First in Human PET Studies with the Next Generation Tau Agent 18-F PI-2620 in Alzheimer’s Disease, Progressive Supranuclear Palsy, and Controls
Olivier Barret, John Seibyl , Andrew Stephens, Jennifer Madonia, David Alagille, Andre Mueller, Mathias Berndt, Heiko Kroth, Francesca Capotosti, Andreas Muhs, Andrea Pfeifer, Gilles Tamagnan, Ludger Dinkelborg, Kenneth Marek


10:15 - 10:30 a.m.

Break


10:30 - 11 a.m.

Chair: Bradford Dickerson

ICI-002
Plenary Session: After Disclosure: Living with an Alzheimer’s Biomarker result
Jason Karlawish, M.D., University of Pennsylvania, United States


11 a.m. - 12:15 p.m.

Chairs:
Victor Villemagne
, AIBL Research Group, Australia
Beth Mormino, Massachusetts General Hospital, USA

IC-02-01 The Relationship of Elevated Medial Temporal Lobe and Diffuse Brain Tau-PET Signal in Clinically Normal Participants Val Lowe

IC-02-02 Relationship Between Tau Positron Emission Tomography with [18F]-AV-1451 and Longitudinal Cortical Atrophy in Alzheimer Disease
Shruti Mishra, Brian Gordon, Tyler Blazey, Yi Su, Jon Christensen, Kelley Jackson, Russ Hornbeck, John Morris, Beau Ances, Tammie Benzinger

IC-02-03 Tau and Hippocampal Volume Reflect Distinct Processes in Preclinical Alzheimer’s Disease
Beth Mormino, Aaron Schultz, Kate Papp, Molly LaPoint, Bernard Hanseeuw, Trey Hedden, Dorene Rentz, Reisa Sperling, Keith Johnson

IC-02-04 Axonal Density Is Associated with Subjective Cognitive Decline (SCD) in Older Adults Assessed Using the Cognitive Change Index
Qiuting Wen, Sourajit Mustafi, Jaroslaw Harezlak, Shannon Risacher, John West, Eileen Tallman, Martin Farlow, Frederick Unverzagt, Liana Apostolova, Andrew Saykin, Yu-Chien Wu

IC-02-05 Abnormal Structural Brain Connectome in Individuals with Preclinical Alzheimer’s Disease
Joana Pereira, Danielle van Westen, Erik Stomrud, Olof Strandberg, Giovanni Volpe, Eric Westman, Oskar Hansson


12:15 – 1:30 p.m.

Lunch (included) & Poster Viewing


1:30 - 2:15 p.m.

DB-01
Data Blitz Presentations

Chairs: David Wolk, M.D., University of Pennsylvania, United States
Victor Villemagne, AIBL Research Group, Australia

DB-01 Modeling and Prediction of the Natural History of Neurodegeneration from Longitudinal Trial Data
Marco Lorenzi, Maurizio Filippone, Daniel Alexander, Sebastien Ourselin

DB-02 Regional Deficit in Sleeping Brain Activity Associated with Tau and Amyloid Pathology in Cognitively Healthy Middle-Aged Adults
Kate Sprecher, Brady Riedner, Henrik Zetterberg, Kaj Blennow, Cynthia Carlsson, Ozioma Okonkwo, Sanjay Asthana, Sterling Johnson, Ruth Benca, Barbara Bendlin

DB-03 Effect of Apoe ε2 on Regional Gray Matter Atrophy and Clinical Phenotype in Alzheimer’s Disease
Colin Groot, Chris van der Weijden, Wiesje van der Flier, Anita van Loenhoud, Bart van Berckel, Frederik Barkhof, Teddy Koene, Charlotte Teunissen, Philip Scheltens, Rik Ossenkoppele

DB-04 Heterogeneity of Hypometabolic Brain Dysfunction in Amnestic MCI: A Hierarchical Clustering Approach Based on Brain-Wide Metabolic Profiles
Michel Grothe, Josh Feitelson, Martin Dyrba, Ralph Buchert, Stefan Teipel

DB-05 Multiple Distinct Atrophy Patterns Found in Genetic Frontotemporal Dementia Using Subtype and Stage Inference (SuStaIn)
Alexandra Young, Razvan Marinescu, Neil Oxtoby, Martina Bocchetta, David Cash, David Thomas, Katrina Dick, M. Jorge Cardoso, Sebastien Ourselin, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni Frisoni, Robert Laforce, Elizabeth Finger, Alexandre Mendonca, Sandro Sorbi, Nick Fox, Jonathan Schott, Jonathan Rohrer, Daniel Alexander

DB-06 Microbleeds Are Associated with Depressive Symptoms in Alzheimer’s Disease
Annebet Leeuwis, Niels Prins, Marije Benedictus, Astrid Hooghiemstra, Philip Scheltens, Geert Jan Biessels, Frederik Barkhof, Wiesje van der Flier

DB-07 Tau Burden Correlates with Longitudinal Structural Change in Regions Affected By Earliest Neurofibrillary Tangle Pathology in Amyloid β Positive Adni Subjects
Long Xie, Sandhitsu Das, Laura Wisse, Ranjit Ittyerah, Paul Yushkevich, David Wolk

DB-08 AV1451-PET Uptake and CSF Biomarkers in a Heterogeneous Clinical Sample: Two Sides of the Same Coin?
Renaud La Joie, Alexandre Bejanin, Anne Fagan, Nagehan Ayakta, Suzanne Baker, Viktoriya Bourakova, Anna Karydas, Gina Jerome, James O'Neil, Julie Pham, Adrienne Visani, Howard Rosen, Adam Boxer, Bruce Miller, William Jagust, Gil Rabinovici

DB-09 Comparison of Binding Properties of THK5117, THK5351, PBB3 and T807 in Autopsies Alzheimer Disease Cases
Laetitia Lemoine, Per-Göran Gillberg, Marie Svedberg, Vladimir Stepanov, Sangram Nag, He Tian, Makoto Higuchi, Christer Halldin, Agneta Nordberg

DB-10 In Vitro Binding Studies to Evaluate the NFT-Specificity of [3h]MK-6240 and [3h]AV-1451 Binding in Subcortical Regions of Human AD Brain
Zhizhen Zeng, Patricia Miller, Brett Connolly, Stacey O’Malley, Talakad Lohith, Idriss Bennacef, James Mulhearn, David Schenk, David Hesk, Abbas Walji, Cyrille Sur, Wenping Li, Eric Hostetler, Jeffrey Evelhoch


2:15 - 3:30 p.m.

Chairs: Jennifer Whitwell, Mayo Clinic, USA
Ann Cohen, University of Pittsburgh, USA

IC-03-01 What Happens to the Hippocampus 12-Months after Training? Longitudinal Linear Mixed Effects Model Analysis of Mild Cognitive Impairment in the SMART Trial.
Michael Valenzuela, Kathryn Broadhouse, Chao Suo, Maria Fiatarone Singh, Nicola Gates, Wei Wen, Perminder Sachdev, Henry Brodaty, Nidhi Jain, Guy Wilson, Jacinda Meiklejohn, Nalin Singh, Bernhard Baune, Michael Baker, Nasim Foroughi, Yi Wang, Yorgi Mavros

IC-03-02 [11c]PK11195 PET in Alzheimer’s Disease and Progressive Supranuclear Palsy: The Nimrod Study
Patricia Vazquez Rodriguez, Luca Passamonti, Young Hong, William Bevan-Jones, Simon Jones, Robert Arnold, Robin Borchert, Ajenthan Surendranathan, Elijah Mak, Li Su, Tim Fryer, Franklin Aigbirhio, John O'Brien, James Rowe

IC-03-03 Regardless of Their Location White Matter Hyperintensities Are Associated with Advanced Brain Aging throughout Adulthood in the Study of Health in Pomerania
Mohamad Habes, Guray Erus, Jon Toledo, RN Bryan, Deborah Janowitz, Jimit Doshi, Henry Voelzke, Ulf Schminke, Wolfgang Hoffmann, Hans Grabe, David Wolk, Christos Davatzikos

IC-03-04 White Matter Hyperintensities in Genetic Frontotemporal Dementia: A Genfi Study
Carole Sudre, Martina Bocchetta, David Cash, David Thomas, Ione Woollacott, Katrina Dick, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonca, Sandro Sorbi, Sebastien Ourselin, M. Jorge Cardoso, Jonathan Rohrer

IC-03-05 Non-Fluent Primary Progressive Aphasia: Prion-like Behavior of Misfolded Proteins in the Syntactic Network
Belen Pascual, Quentin Funk, Elijah Rockers, Neha Pal, Paolo Zanotti-Fregonara, Meixiang Yu, Christof Karmonik, Bryan Spann, Paul Schulz, Joseph Masdeu


3:30 - 3:45 p.m.

Break


3:45 - 4 p.m.

Presentation of the Neuroimaging Awards

Presented by: Dave, Victor, and Brad


4 - 5 p.m.

Chair: Victor Villemagne, AIBL Research Group, Australia

Debate: Biomarkers in Clinical Trials
Rachelle Doody, M.D., Ph.D., Roche/Genetech, Switzerland
Nick Fox, Ph.D., University College London, England

5 - 5:30 p.m.

Closing Remarks

David Wolk, M.D.
Chair, Neuroimaging Professional Interest Area (NIPIA); University of Pennsylvania, United States

6 – 7 p.m.

ISTAART Neuroimaging PIA Business Meeting (ISTAART members only; location to be announced)



*Agenda subject to change.

Neuroimaging PIA business meeting

The ISTAART Neuroimaging PIA Business Meeting will take place immediately following AIC at 5:45 p.m. (the location will be announced at a later date).

Target audience

All clinicians involved in the care or research of individuals with memory or other cognitive complaints, including but not limited to neurologists, psychiatrists, radiologists, geriatricians, neuropsychologists, physicians and nurses; researchers, industry and regulatory agency stakeholders; and others involved in the use of imaging techniques in the study of Alzheimer’s disease, related disorders and normal aging.

Registration

AIC is a preconference to AAIC 2017. Preconferences require a separate registration fee in addition to AAIC full conference registration or it may be purchased as a stand-alone event. View registration information.

AIC registration fellowships

A limited number of fellowships, in the form of complimentary AIC registration, are available for early career scientists who are the presenting author on an accepted abstract. (The application process for AIC 2017 is closed.)

About ISTAART

ISTAART logo

The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) is a professional society for individuals interested in Alzheimer's and dementia science—including scientists, physicians and other professionals involved in the causes and treatments of Alzheimer's disease and other dementias. ISTAART membership makes AAIC even better: receive discounted registration, participate in professional interest areas (PIA), attend PIA Day scientific sessions (Saturday, July 15) and attend exclusive member-only scientific and networking events. Members also receive ongoing benefits throughout the year, including an online monthly subscription to Alzheimer's & Dementia: The Journal of the Alzheimer's Association, free online access to Neurobiology of Aging, access to the online career center, monthly e-newsletters, networking forums and extended LOI deadlines for the Alzheimer's Association International Research Grant Program.

Non-members are encouraged to learn more and join ISTAART. Non-members may also join ISTAART during AAIC registration -- select "Member +PLUS" or "Student Member +PLUS " as the AAIC registration category to purchase one year of ISTAART membership in addition to AAIC registration at the member rate. Available to new members only.



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