Educational Workshop: How to Interpret the Neuropathology Sign-Out Report

Alzheimer’s Disease Pathology Under the Microscope and How to Report It (for Clinicians and Scientists)

Friday, July 12, 2019
8 a.m. – 5 p.m.
Intercontinental Los Angeles Downtown Hotel, Roosevelt

Overview

This workshop is intended to provide the participant with an understanding of the basic neuropathological features of age-associated neurodegenerative diseases. This will include neuropathological hallmark lesions that are seen in Alzheimer’s disease, primary tauopathies, α- synucleinopathies, diseases displaying inclusions with transactive DNA binding protein and various vascular lesions. Common consensus criteria applied during case assessment will also be discussed.

The workshop will consist of both interactive lectures and practical sessions. Numerous scanned histological slides will be assessed to provide information on how the observed lesions are interpreted (i.e. identify certain lesion, assess its extent and state its clinical relevance). A number of cases will be presented and discussed, including their clinical phenotype, the neuropathological observations, classification applied and the interpretation leading to a final diagnosis. The participant should gain a solid and lasting knowledge of the basics covered (i.e. various neuropathological lesions listed in a sign-out report and the classifications applied).

The organizers believe that the basic principles of neuropathology in neurodegeneration need to be understood by non-neuropathologists physicians and scientists. This understanding is vital in the interpretation of neuropathological data while reading sign-out reports and in the planning and conducting of scientific studies.

Organizing Committee


Agenda
  • Time
  • Topics

8 a.m.

Welcome and Opening Remarks
Irina Alafuzoff, Uppsala University, Sweden


8:05 a.m.

Short Summary of Methods (emphasis on brain cutting, IHC methods)
Irina Alafuzoff, Uppsala University, Sweden


8:20 a.m.

Hyperphosphorylated Tau in Alzheimer’s Disease / Assessment of the Stage
Irina Alafuzoff, Uppsala University, Sweden


8:40 a.m.

β-Amyloid in the Parenchyma / Assessment of Phase
Dietmar Thal, KU Leuven, Belgium


9 a.m.

CERAD
Dietmar Thal, KU Leuven, Belgium


9:10 a.m.

Consensus Criteria (ADNC, PART and subtypes of AD)
Melissa E. Murray, Mayo Clinic, United States


10 a.m.

Break


10:30 a.m.

Primary Tauopathies (including ARTAG)
Gabor Kovacs, Medical University of Vienna, Austria


11:10 a.m.

Neuronal and Glial α-Synuclein / Staging
Irina Alafuzoff, Uppsala University, Sweden


11:30 a.m.

Transactive DNA Binding Protein (including LATE)
Irina Alafuzoff, Uppsala University, Sweden; Gabor Kovacs, Medical University of Vienna, Austria


12 p.m.

Vascular Lesions
Dietmar Thal, Belgium


12:20 p.m.

Lunch (included)


1 - 5 p.m.

Presentation of cases (at least 16) + joint assessment of scanned slides + assessment of neuropathological changes + staging of extent + definite diagnosis + discussion related to clinical relevance
(Poll Everywhere (a mobile app polling system) will be used so presenters and attendees can interact.)


Target Audience

Physicians independent of sub-specialties, students, postdoctoral trainees looking to build a basic foundation or refresh their knowledge in neuropathology.

Registration

Educational workshops come with separate registration fees in addition to AAIC full conference registration. Workshops can also be purchased as stand-alone events. Registration for this workshop opened in February.

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