Educational Workshop: Basic Neuropathology of Age-Associated Neurodegenerative Diseases

Friday, July 14, 2017
8 a.m. – 5 p.m.
Intercontinental O2 Hotel, Room: Aurora 12-14
London, England

 

The workshop is intended to provide the participant with an understanding of the basic neuropathological features of age associated neurodegenerative diseases. This will include neuropathological hallmark lesions (e.g., amyloid-β plaques, neuritic plaques, neurofibrillary tangles/threads, Lewy bodies/neurites etc.) and an explanation of how these lesions are assessed to classify diseases (e.g., neuritic Braak stages, amyloid-β phases, CERAD score, NIA-AA criteria, McKeith Criteria etc.).

The workshop will consist of both lectures and practical sessions; over 250 scanned (immuno) histological slides are already available to be examined using Aperio software and participants can easily access those slides using their own laptop/tablet/smart phone. By attending this workshop, the participant should gain a solid and lasting knowledge of the basics covered (e.g., difference amyloid-β plaques vs neuritic plaques and why this difference matters). The organizers believe that basic principles of neuropathology in neurodegeneration can be understood by non-neuropathologists and such an understanding should be helpful not only in interpreting neuropathological data but also in the planning and conducting of scientific studies.

Of note, the workshop is not intended to showcase the most recent neuropathological developments that would be of interest to an audience already familiar with neuropathology. Therefore the workshop should be of interest for students, Ph.D.s and physicians looking to build a basic foundation or refresh their knowledge.

Participants should bring their own device (laptop, tablet, etc.) to access data (slides) that are provided online.

Most sessions are divided into lecture and practical parts. Lectures will be interactive, i.e., participants are encouraged to ask questions. During practical parts, participants will have access to electronic slides and should apply the lectures’ contents (e.g., if the lecture covers Braak stages, the participants will assign Braak stages to various cases).

Agenda
  • Time
  • Topics

8 a.m.

Opening Remarks
Johannes Attems, United Kingdom


8:15 a.m.

Neuroanatomy
Dietmar Thal, Germany
Lecture: Neuroanatomical basics for the diagnosis of neurodegenerative diseases


8:30 a.m.

Amyloid
Dietmar Thal, Germany
Lecture: Basics, plaques, CAA, amyloid phases Practical: State amyloid deposition types (subpial band like, fleecy, diffuse, dense); distinguish between CAA and capCAA, assign amyloid phases


9:30 a.m.

Hyperphosphorylated tau
Kurt Jellinger, Austria
Lecture: Basics, tangles/ threads, Braak stages, Primary Age Related Tauopathy (PART) Practical: Assign Braak stages to cases


10:30 a.m.

Break


11 a.m.

The neuropathological diagnosis of Alzheimer's disease
Kurt Jellinger, Austria
Lecture: CERAD scores, NIA-AA Practical: Assign NIA-AA score to cases


12 p.m.

Lewy body diseases
Irina Alafuzoff, Sweden
Lecture: Basics, lewy bodies/neurites, McKeith/ Braak a-syn stages, concept Lewy body diseases (dementia with Lewy bodies, Parkinson's dementia, Parkinson's disease) Practical: assign McKeith/ Braak a-syn stages


12:45 p.m.

Lunch (included)


2 p.m.

Cerebrovascular pathology
Dietmar Thal, Germany
Lecture: examples for cerebrovascular pathology e.g. large and small vessel disease, hemorrhage, infarcts
Practical: state severity of atherosclerosis, SVD, white matter pallor, deep gray matter lesions, distinguish fresh/ old infarct


2:45 p.m.

TDP-43
Irina Alafuzoff, Sweden
Lecture only: brief overview of TDP-43 proteinopathies


3 p.m.

Multimorbidity of the "old" human brain (overlap of pathologies)
Johannes Attems, United Kingdom
Lecture: recapitulate morning (staging), emphasize high co-occurrence of pathologies (ie multimorbdidity) incl findings from large autopsy studies. Discuss TDP-43 in AD.
Practical: give NIA-AA, McKeith to mixed cases, spot TDP-43.


3:30 p.m.

Break


3:45 p.m.

Clinico-pathological correlative studies and neurodegeneration
Melissa E. Murray, United States
Lecture only: Role of post-mortem neuropathological examination as quality control/ feedback for the clinician (clinical diagnosis, drug trials).


4:15 p.m.

Neuropathological examination of various cases
Practical only: Participants examine various cases


5 p.m.

Conclusion


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