Emerging Concepts in Basic Science

After great success in 2016, this series highlighting basic dementia science will be a can't-miss aspect of AAIC 2017.

The Scientific Program Committee introduced the Emerging Concepts series, an innovative aspect of the AAIC program designed specifically for basic dementia science.

One Emerging Concepts session will be held each day from Sunday to Tuesday of the conference, concluding with a panel discussion on Wednesday that includes the three session leads.

2017 Emerging Concepts Sessions

The Emerging Concepts series will focus on three areas:

Emerging Concepts in the Biology of Frontotemporal Lobar Degeneration

Lead: Michel Goedert

Frontotemporal lobar degeneration (FTLD) is clinically, pathologically and genetically heterogeneous, but affects predominantly the frontal and temporal lobes of the cerebral cortex. There are three main clinical syndromes (behavioural-variant frontotemporal dementia, semantic dementia and progressive non-fluent aphasia), three predominant histologies (involving Tau, TDP-43 and FUS) and three major genetic causes (mutations in MAPT, GRN AND C9orf72). In recent years, much progress has been made, resulting in a better understanding of the biology underlying the clinical syndromes of FTLD. This Symposium aims to reflect major recent developments. Bernardine Ghetti will give an overview of FTLD, linking the clinical syndromes with histology and genetics. Sjors Scheres will present the atomic structures of Tau filaments obtained by cryo-electron microscopy. They are the first such structures of an amyloid fibril and indicate paths towards novel diagnostics and therapeutics for Tauopathies.Masato Hasegawa will talk about the RNA-binding proteins TDP-43 and FUS and their roles in FTLD. TDP-43 inclusions are the most common pathological characteristic of FTLD. Chris Shaw will talk about frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) and the hexanucleotide expansions in C9orf72, the most recently identified and most common genetic cause of FTLD.

Individual Talks:

Emerging Concepts: Peripheral Influences of Adaptive and Innate Immunity on CNS Pathology in Alzheimer’s Disease

Lead: Clive Holmes

Recent studies highlight the role of peripheral innate and adaptive immunity in the pathophysiology of Alzheimer’s disease (AD). Changes in peripheral innate and adaptive immunity occurring in response to peripheral inflammatory events have a direct influence on the brain’s immune response and other aspects of brain pathology in AD.

This series of lectures will examine aspects of both peripheral innate and adaptive immunity in AD, with a focus on the effects of systemic infections on brain pathology in both human studies and murine models of AD at different stages of the disease. We show evidence that changes in peripheral immunity modulate various aspects of disease pathology in AD including amyloid-β deposition, T-cell infiltration, the CNS innate immune response and alterations in the clinical course of the disease. The evidence suggests that in AD the central response to these peripheral challenges involves aspects of both innate and adaptive immunity and is likely to change over the time course of the disease. Possible immunotherapeutic strategies will be discussed.

Individual Talks:

Emerging Concepts: Protein Clearance in Dementia

Lead: Roxana Carare

Session description coming soon



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