ARGENTINA
Eduardo M. Castaño, M.D.
Instituto de Química y Fisicoquímica Biológicas (Institute of Biological and Physical Chemistry)
Buenos Aires, Argentina
The Role of Insulin-Degrading Enzyme in the Pathogenesis of Cerebral Beta-Amyloid
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
AUSTRALIA
Peter R. Dodd, Ph.D.
University of Queensland
Brisbane, Australia
Glutamate Transporter Protein Expression and Its Relationship to Alzheimer’s Disease
Investigator-Initiated Research Grant — $161,212 over three years
Supported through the generosity of the Quest for a Cure Campaign *
CANADA
Sandra E. Black, M.D.
University of Toronto
Toronto, Ontario
MRI Hyperintensities and Executive Deficits in Alzheimer’s Disease (AD): A Quantitative Neuroimaging-Behavioral Analysis
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Janice Keefe, Ph.D.
Mount Saint Vincent University
Halifax, Nova Scotia
From Research to Practice: Assessing Caregivers of Persons with Alzheimer’s Disease, an Evaluative Study
Investigator-Initiated Research Grant — $239,074 over three years
Supported through the generosity of the Quest for a Cure Campaign *
James McLarnon, Ph.D.
University of British Columbia
Vancouver, British Columbia
Mechanisms and Modulation of Calcium Dependent Signaling in Beta-Amyloid Stimulated and Alzheimer’s Disease Human Microglia
Investigator-Initiated Research Grant — $222,150 over three years
Supported through the generosity of the Quest for a Cure Campaign *
David Westaway, Ph.D.
University of Toronto
Toronto, Ontario
Interactions of Tau and Amyloid Pathologies in the CNS of Transgenic Mice
Zenith Fellows Award — $248,666 over two years
Supported through the generosity of the Zenith Fellows
ITALY
Massimo L. Tabaton, M.D.
University of Genoa
Genoa, Italy
Pattern of Soluble Beta-Amyloid Species in Cerebral Cortex from Nondemented Aged Subjects: The Molecular Substrate of Beta-Amyloid Toxicity
Investigator-Initiated Research Grant — $200,000 over two years
Supported through the generosity of the Sons of Italy
SWEDEN
Ingmar Skoog, M.D., Ph.D., D.Sc.
Institute of Clinical Neurosciences
Göteborg, Sweden
Longitudinal Population Study on Alzheimer’s Disease and other Dementias after Age 95
Investigator-Initiated Research Grant — $237,500 over two years
Supported through the generosity of the Quest for a Cure Campaign *
Bengt Winblad, M.D., Ph.D.
Karolinska Institute
Stockholm, Sweden
Exploring the Hypothesis that an Active Life and Rigorous Health Control in Late Life Decrease the Risk of Alzheimer disease and Dementia
Investigator-Initiated Research Grant — $221,100 over three years
Supported through the generosity of the Ambrose Monell Foundation *
UNITED KINGDOM
Robert Stewart, M.D.
Institute of Psychiatry
London, United Kingdom
Ascertaining Cognitive Function and Dementia in African-Caribbean Populations
Investigator-Initiated Research Grant — $224,706 over three years
Supported through the generosity of the Quest for a Cure Campaign *
UNITED STATES
Arizona
Yong Shen, M.D., Ph.D.
Sun Health Research Institute
Sun City, Arizona
Regulation of Beta-Secretase (BACE) in Alzheimer’s Disease Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Arkansas
Yuekui Li, M.D., Ph.D.
University of Arkansas for Medical Sciences
Little Rock, Arkansas
IL-1 Mediated Glial-Neuronal Interactions Impacting Neuronal Cytoskeleton and Connectivity
New Investigator Research Grant — $99,916 over two years
Supported through the generosity of the Quest for a Cure Campaign *
California
Michael G. Agadjanyan, Ph.D., D.Sc.
Institute for Molecular Medicine
Huntington Beach, California
Detection of Beta-Amyloid Mimotopes in Vaccinated AD Patients
Investigator-Initiated Research Grant — $239,989 over three years
Margaret C. Barr, D.V.M., Ph.D.
Vaccine Research Institute of San Diego
San Diego, California
Development of a Hepatitis Virus Core-Based Alzheimer's Disease Vaccine
Investigator-Initiated Research Grant —$240,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
William H. Batchelder, Ph.D.
University of California at Irvine
Irvine, California
Developing Culturally Appropriate Screening Tools for Dementia
Investigator-Initiated Research Grant — $185,313 over three years
Designated a Research Roundtable grant
Jorge A. Busciglio, Ph.D.
University of California at Irvine
Irvine, California
Cellular Mechanisms of Amyloid Beta-Induced Neuronal Dystrophy
Investigator-Initiated Research Grant — $239,403 over three years
Karen H. Gylys, R.N., Ph.D.
University of California at Los Angeles
Los Angeles, California
Apolipoprotein E-e4 Effects on AD Pathology and Synapse Loss
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of the Alzheimer's Association - Los Angeles, Riverside and San Bernardino Counties Chapter
Ming Guo, M.D., Ph.D.
University of California at Los Angeles
Los Angeles, California
Identifying Regulators for Gamma Secretase
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of the Templeton Medical Research Foundation
Elizabeth Head, Ph.D.
University of California at Irvine
Irvine, California
Effects of Chronic Treatment of Atorvastatin on Beta-Amyloid Production in the Aged Canine
Investigator-Initiated Research Grant — $239,971 over three years
Edward H. Koo, M.D.
University of California at San Diego
La Jolla, California
APP-Induced Gene Transcription: Role in Alzheimer’s disease
Investigator-Initiated Research Grant — $92,800 over one year
Supported through the generosity of the Judy Gelfand Fund
Olivera M. Mitrasinovic, Ph.D.
Stanford University Medical Center
Stanford, California
Accelerated Clearance of Beta-Amyloid Peptide and Beta-Amyloid Plaques by Microglia Overexpressing the M-CSF Receptor
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of the Quest for a Cure Campaign *
Shaunna K. Morris, Ph.D.
University of California at San Diego
San Diego, California
Sensitivity of an fMRI Picture Classification Paradigm in Detecting Mild Memory Impairment in Bilingual Mexican Americans
New Investigator Research Grant — $98,451 over two years
Vasanthy Narayanaswami, Ph.D.
Children’s Hospital – Oakland
Oakland, California
Molecular Spectroscopic Analysis of Apolipoprotein E / Lipid / Beta-Amyloid Peptide Interaction
T.L.L. Temple Foundation Discovery Award — $250,000 over three years
Supported through the generosity of the T.L.L.Temple Foundation
Ina C. Tesseur, Ph.D.
Stanford University Medical Center
Palo Alto, California
Lipoprotein-Associated TGF-Beta1 as a Mediator of ApoE Function in Neurodegeneration
New Investigator Research Grant —- $100,000 over two years
Supported through the generosity of the Quest for a Cure Campaign *
Gang Tong, M.D., Ph.D.
University of California at San Diego
La Jolla, California
Roles of Beta-Amyloid Oligomers in Synaptotoxicity and Pathogenesis of Alzheimer’s Disease
New Investigator Research Grant — $99,480 over two years
Supported through the generosity of the Quest for a Cure Campaign *
Mark H. Tuszynski, M.D., Ph.D.
University of California at San Diego
La Jolla, California
BDNF Treatment of Entorhinal Neuronal Degeneration in Alzheimer’s Disease
T.L.L. Temple Foundation Discovery Award —$238,839 over two years
Supported through the generosity of the T.L.L.Temple Foundation
Huaxi Xu, Ph.D.
Burnham Institute
La Jolla, California
Presenilins Regulate Trafficking of APP and Components of the Gamma-Secretase Complex
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Connecticut
Karyn M. Frick, Ph.D.
Yale University
New Haven, Connecticut
Impact of Environmental Experience on Mnemonic Response to Estrogen in Aging Mice
Investigator-Initiated Research Grant —$239,989 over three years
Supported through the generosity of the National Association of Retired Federal Employees
Florida
Kiminobu Sugaya, Ph.D.
University of Central Florida
Orlando, Florida
Beta-Amyloid Precursor Protein Function in Neural Stem Cell Biology
Investigator-Initiated Research Grant — $239,990 over three years
Supported through the generosity of the Hille Family Foundation
Georgia
Felicia C. Goldstein, Ph.D.
Emory University
Atlanta, Georgia
Vascular Risk Factors and Neurobehavioral Functioning in AD Patients
Senator Mark Hatfield Award for Clinical Research in Alzheimer’s Disease — $239,818 over three years
Richard A. Kahn, Ph.D.
Emory University
Atlanta, Georgia
Regulation of APP Traffic and Processing by Arfs and MINTs
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Hawaii
Lon White, M.D., M.P.H.
Pacific Health Research Institute
Honolulu, HI
Genetic Markers of Inflammation and the Risk for Alzheimer’s Disease in a Japanese-American Population
Investigator-Initiated Research Grant — $240,000 over three years
Illinois
Ken-ichiro Fukuchi, Ph.D.
University of Illinois at Peoria
Peoria, Illinois
Muscle-Directed Immune Gene Therapy for Alzheimer s Disease
Zenith Fellows Award — $250,000 over two years
Supported through the generosity of the Zenith Fellows
Yoshitaka Ishii, Ph.D.
University of Illinois
Chicago, Illinois
Structural Studies of Alzheimer’s Beta-Amyloid Peptides in Protofibril and Fibril Aggregates
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of the Hille Family Foundation
Seong-Hun Kim, M.D., Ph.D.
University of Chicago
Chicago, Illinois
Role of PEN-2 in the Stabilization and Endoproteolysis of Presenilin-1
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of the Bankers Life and Casualty Co.
Iowa
Daniel M. Quinn, Ph.D.
University of Iowa
Iowa City, Iowa
Synthesis and Evaluation of Inhibitors of Acetylcholinesterase Based on the Trifluoroketone Pharmacophore
T.L.L. Temple Foundation Discovery Award — $250,000 over three years
Supported through the generosity of the T.L.L.Temple Foundation
Maine
Robert W. Burgess, Ph.D.
Jackson Laboratory
Bar Harbor, Maine
An Analysis of Heparansulfate Proteoglycans in Beta-Amyloid Plaque Formation
New Investigator Research Grant —$100,000 over two years
Supported through the generosity of the Quest for a Cure Campaign *
Maryland
Jiska Cohen-Mansfield, Ph.D.
Research Institute of the Hebrew Home for Greater Washington
Rockville, Maryland
The Utility of Pain Assessment for Analgesic Use in Persons with Dementia
Zenith Fellows Award — $250,000 over two years
Supported through the generosity of the Zenith Fellows
Vera A. Golovina, Ph.D.
University of Maryland
Baltimore, Maryland
Presenilins, the Endoplasmic Reticulum and Store-Operated Calcium Entry in Astrocytes from the Trisomy 16 Mouse, an Animal Model of Alzheimer’s Disease
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the Hille Family Foundation
Massachusetts
John A. Ladias, M.D.
Beth Israel Deaconess Medical Center
Boston, Massachusetts
Molecular Mechanisms of Amyloid Precursor Protein Function
T.L.L. Temple Foundation Discovery Award — $250,000 over three years
Supported through the generosity of the T.L.L.Temple Foundation
Marta M. Lipinski, Ph.D.
Harvard Medical School
Boston, Massachusetts
Role of the Caspase Family Proteases in Alzheimer’s Disease
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of the Pine Family Foundation
Evgeny I. Rogaev, Ph.D., D.Sc.
University of Massachusetts
Worcester, Massachusetts
Interaction between Presenilin-Related Putative Proteases and Alzheimers Disease Pathway
T.L.L. Temple Foundation Discovery Award — $250,000 over three years
Supported through the generosity of the T.L.L.Temple Foundation
Agustin G. Yip, MD, PhD
Boston University School of Medicine
Boston, Massachusetts
Genetic Basis of Cerebrovascular Mechanisms in Alzheimer’s Disease
New Investigator Research Grant — $99,998 over two years
Supported through the generosity of the National Association of Retired Federal Employees
Michigan
Peter A. Lichtenberg, PhD
Wayne State University
Detroit, Michigan
Easing the Transition to Long Term Care: A Peer Mentorship Program for Urban African-American Caregivers and Persons with Dementia
Investigator-Initiated Research Grant — $160,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Kristen J. Verhey, PhD
University of Michigan
Ann Arbor, Michigan
Role of Kinesin-I and JIP1 in APP Trafficking
New Investigator Research Grant —$100,000 over two years
Minnesota
James P. Cleary, PhD
University of Minnesota
Minneapolis, Minnesota
Cognition in an APP and Tau Overexpressing Mouse Model of AD
Investigator-Initiated Research Grant — $239,629 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Kejal Kantarci, M.D.
Mayo Clinic
Rochester, Minnesota
Predicting Future Progression to Dementia in People with Different Mild Cognitive Impairment Syndromes Using H-1 Magnetic Resonance Spectroscopy
New Investigator Research Grant — $98,491 over two years
Supported through the generosity of the Pearson Family in care of the Minnesota/Dakota chapter of the Alzheimer's Association
Missouri
James E. Galvin, MD
Washington University
St. Louis, Missouri
Exploring Psychosocial Determinants of Intention to Screen for Memory Loss
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Raphael Kopan, PhD
Washington University
St. Louis, Missouri
The Oligomeric State of Presenilin and Substrates within Gamma-Secretase
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of Charles and Joanne Knight and the Emerson Electric Company in care of the Alzheimer's Association - St. Louis Chapter
Ann M. Steffen, PhD
University of Missouri at St. Louis
St. Louis, Missouri
Distance-Based Interventions for Depressed Dementia Family Caregivers: Three-Year Longitudinal Assessment
Investigator-Initiated Research Grant — $231,710 over three years
Supported through the generosity of the Quest for a Cure Campaign *
New Jersey
Robert G. Nagele, PhD
University of Medicine and Dentistry of New Jersey
Stratford, New Jersey
Intracellular Beta-Amyloid Accumulation and Neuronal Degeneration in Alzheimer’s Disease
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of AWARE in care of Alzheimer's Association - Rocky Mountain Chapter
New York
Ottavio Arancio, MD, PhD
The Nathan Kline Institute
Orangeburg, New York
Neuronal RAGE and Amyloid-Beta Peptide-Induced Perturbation of Synaptic Plasticity
Investigator-Initiated Research Grant — $239,974 over three years
Jannic Boehm, PhD
Cold Spring Harbor Laboratory
Cold Spring Harbor, New York
Molecular Mechanisms of Regulated AMPA Receptor Trafficking
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of the Blanchette Hooker Rockefeller Fund *
Desiree A. Byrd, PhD
Columbia University
New York, New York
Neuropsychological Tests as Predictors of Functional Status in African-American, Hispanic, and Caucasian Elders: A Retrospective Study
New Investigator Research Grant — $99,998 over two years
Supported through the generosity of the Quest for a Cure Campaign *
David J. E. Callaway, PhD
The North Shore/Long Island Jewish Research Institute
Manhasset, New York
Structural Determinants of Amyloid Fibril Formation
Investigator-Initiated Research Grant — $232,065 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Luciano D’Adamio, MD, PhD
Albert Einstein College of Medicine
Bronx, New York
Regulation of MAPK by APP
T.L.L. Temple Foundation Discovery Award — $250,000 over two years
Supported through the generosity of the T.L.L.Temple Foundation
Jorge A. Ghiso, PhD
New York University
New York, New York
Catabolism of Beta-Amyloid by the Liver: A Step Toward the Understanding of Beta-Amyloid Physiopathology
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the 2003 Rita Hayworth Gala auction *
Gunnar K. Gouras, MD
Cornell University Medical College
New York, New York
Regulation of MVB Beta-Amyloid Accumulation
T.L.L. Temple Foundation Discovery Award — $250,000 over three years
Supported through the generosity of the T.L.L.Temple Foundationand Marian Littleford Foundation
Koichi Iijima, PhD
Cold Spring Harbor Laboratory
Cold Spring Harbor, New York
Studying Abeta Catabolism in Drosophila AD Model
New Investigator Research Grant — $100,000 over two years
Fei Liu, PhD
New York State Institute for Basic Research
Staten Island, New York
Role of Protein Phosphatase 5 in Tau Phosphorylation
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of the Quest for a Cure Campaign *
Ralph A. Nixon, MD, PhD
Nathan S. Kline Institute for Mental Hygiene
Orangeburg, New York
Amyloidogenic Mechanisms in Sporadic AD
Zenith Fellows Award — $249,262 over two years
Supported through the generosity of the Zenith Fellows
North Carolina
Peggye Dilworth-Anderson, DPhil
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Perceiving and Giving Meaning to Dementia Among Caregivers for African-American and White Elders: Rural and Urban Differences
Investigator-Initiated Research Grant — $239,998 over three years
Guy G. Potter, PhD
Duke University Medical Center
Durham, North Carolina
Occupational Complexity, Healthy Aging, and Dementia in Older Twin Pairs
New Investigator Research Grant — $81,683 over two years
Ohio
Katrina A. B. Goddard, PhD
Case Western Reserve University
Cleveland, Ohio
Candidate Genes in Very Late-Onset Alzheimers Disease
New Investigator Research Grant — $99,971 over two years
Supported through the generosity of the National Association of Retired Federal Employees
Mark A Smith, PhD
Case Western Reserve University
Cleveland, Ohio
Signal Transduction Alterations in Alzheimer's Disease
Investigator-Initiated Research Grant — $240,000 over three years
Jack C. de la Torre, MD, PhD
Case Western Reserve University
Cleveland, Ohio
The Role of Nitric Oxide and Endothelial Function in Rat Chronic Brain Hypoperfusion
Investigator-Initiated Research Grant — $239,371 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Pennsylvania
Steven E. Arnold, MD
University of Pennsylvania
Philadelphia, Pennsylvania
Brain Insulin Signaling and Pathology in Healthy Aging, Mild Cognitive Impairment, and Alzheimer’s Disease
T.L.L. Temple Foundation Discovery Award — $250,000 over three years
Supported through the generosity of the T.L.L.Temple Foundation
Judith A. Erlen, PhD, RN, FAAN
University of Pittsburgh
Pittsburgh, Pennsylvania
Understanding the Medication-Taking Process in Persons with Alzheimer’s Disease
Investigator-Initiated Research Grant — $183,227 over two years
Supported through the generosity of the Quest for a Cure Campaign *
V. Kodavali Chowdari Ph.D.
University of Pittsburgh
Pittsburgh, Pennsylvania
Genetic Analysis of Alzheimer’s Disease with Psychosis
New Investigator Research Grant — $99,512 over two years
Supported through the generosity of the Hille Family Foundation
Diana S. Woodruff-Pak, PhD
Albert Einstein Healthcare Network
Philadelphia, Pennsylvania
Screening and Assessment in a Diverse Sample
Investigator-Initiated Research Grant — $240,000 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Rhode Island
Stephen Correia, PhD
Rhode Island Hospital
Providence, Rhode Island
Working Memory and Frontal White Matter Integrity in Mild Cognitive Impairment
New Investigator Research Grant — $99,157 over two years
Supported through the generosity of the Quest for a Cure Campaign *
William C. Heindel, PhD
Brown University
Providence, Rhode Island
Behavioral and Electrophysiological Investigation of Semantic Memory In Alzheimer’s Disease
Investigator-Initiated Research Grant — $182,160 over three years
Supported through the generosity of the Hille Family Foundation
Edward G. Stopa, MD
Rhode Island Hospital
Providence, Rhode Island
Blood / CSF Barrier Function in Aging and Alzheimer’s Disease
T.L.L. Temple Foundation Discovery Award — $250,000 over three years
Supported through the generosity of the T.L.L.Temple Foundation
Texas
Peter Koulen, Ph.D.
University of North Texas
Fort Worth, Texas
Modulation of Calcium Signaling by Presenilin-1
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of Dr. James W. Simpkins, Mrs. E.M. Rosenthal, and several community donors
Gang G. Yu, Ph.D.
University of Texas Southwestern Medical School
Dallas, Texas
Studies of Nimp-1, a Novel Nicastrin-Interacting Membrane Protein
New Investigator Research Grant — $100,000 over two years
Supported through the generosity of The Kinder Foundation *
Hui Zheng, Ph.D.
Baylor College of Medicine
Houston, Texas
Delineating APP Functional Domains and Identifying APP Downstream Targets
Zenith Fellows Award —$250,000 over two years
Supported through the generosity of the Zenith Fellows
Virginia
Karen A. Roberto, Ph.D.
Virginia Polytechnic Institute and State University
Blacksburg, Virginia
Caregivers of Persons with Mild Cognitive Impairment: Information and Support Needs
Investigator-Initiated Research Grant — $239,975 over three years
Supported through the generosity of the Quest for a Cure Campaign *
Washington
Paul K. Crane, M.D.
University of Washington
Seattle, Washington
Improving Screening Tests for Dementia
New Investigator Research Grant — $58,077 over one year
Supported through the generosity of the Quest for a Cure Campaign *
Rebecca G. Logsdon, Ph.D.
University of Washington
Seattle, Washington
Efficacy of Early-Stage Alzheimer’s Disease Support Groups
Investigator-Initiated Research Grant — $239,854 over three years
Supported through the generosity of the Directors' Fund of the Alzheimer's Association national board of directors
Randall T. Moon, Ph.D.
University of Washington
Seattle, Washington
Apolipoprotein E and Wnt Signal Transduction in Alzheimer’s disease
T.L.L. Temple Foundation Discovery Award — $249,678 over three years
Supported through the generosity of the T.L.L.Temple Foundation
Chang-En Yu, Ph.D.
Seattle Institute for Biochemical and Clinical Research
University of Washington
Seattle, Washington
APOE Gene-Based Haplotype Study in Alzheimer's Disease
New Investigator Research Grant — $199,976 over one year
Supported through the generosity of Mr. Jack Tonkin * and the Western Washington Chapter of the Alzheimer's Association *
