Donate Now
Research Grants - 2005


Alzheimer's Assocation Research only
All of alz.org
  • Go to Alz.org
  • Research Center
  • AAIC
  • ISTAART
  • Journal
  • Grants
  • TrialMatch
  • Press
  • Donate
  • Contact Us
Home
Science and Progress
Clinical Trials
Funding and Collaboration
You can Help
Stay Current
Video and Resources

Text Size

Small text Medium text Large text

Research Grants 2005


To view an abstract, select an author from the vertical list on the left side.

2005 Grant - Wang

High-Resolution NMR of ABAD-Abeta Interaction

Chunyu Wang, M.D., Ph.D.
Rensselaer Polytechnic Institute
Troy, New York

2005 New Investigator Research Grant

Researchers have long suspected that the tiny beta-amyloid protein fragment has a toxic effect on cells in the Alzheimer brain. The exact means by which beta-amyloid damages cellular structures or disrupts normal cellular function is not clear.

Recent evidence suggests that beta-amyloid interacts with a molecule called Abeta-binding alcohol dehydrogenase (ABAD). ABAD plays an important role in mitochondria, the energy-producing structures in cells. When beta-amyloid interacts with ABAD, the molecule's normal work may be blocked, possibly resulting in mitochondrial dysfunction and triggering other potentially toxic events in a cell.

Chunyu Wang, M.D., Ph.D., and colleagues are using a nuclear magnetic resonance (NMR) technology that will enable them to produce atomic-
level, high-resolution images of beta-amyloid and ABAD. This may reveal properties of both molecules that cause each one to bind to the other.

The data from the investigation may provide valuable information for a "made-from-scratch" approach to design a therapeutic compound that thwarts the ABAD–beta-amyloid interaction and prevents subsequent toxic events. The work may, therefore, lay the foundation for a disease-modifying therapy addressing a relatively early stage of the Alzheimer's disease process.