To view an abstract, select an author from the vertical list on the left side.
2008 Grants - Lamb
A Humanized Mouse Model of Alzheimer's Disease
Bruce T. Lamb, Ph.D.
Cleveland Clinic Foundation
2008 Investigator-Initiated Research Grant
Alzheimer's disease involves several different pathological hallmarks in the brain. These hallmarks include accumulations of the protein fragment beta-amyloid, tangles of abnormal tau protein, evidence of damaged cell-to-cell communication and loss of nerve cells. Yet scientists know little about how all of these features are interrelated. Such knowledge is critical for the development of more effective Alzheimer therapies.
Bruce T. Lamb, Ph.D., and colleagues plan to address the issue by engineering a "humanized" mouse model of Alzheimer's disease. This model will contain complete copies of human gene mutations that increase the risk of obtaining familial, or inherited, Alzheimer's. The researchers hope to use their mice to identify biological factors underlying the different Alzheimer pathologies. Primarily, Dr. Lamb's team hopes to examine the complex relationships between abnormal tau tangles and beta-amyloid accumulations.