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2010 Grants - Frisoni
A Harmonized Protocol for Hippocampal Volumetry: An EADC-ADNI effort
Giovanni B. Frisoni, M.D.
Fatebenefratelli Association for Research
2010 Investigator-Initiated Research Grant
Currently, there is no standard brain imaging method for diagnosing Alzheimer's disease. It is known, however, that a region of the brain known as the hippocampus decreases in size as the disease develops. Thus, a standardized and validated method to measure the volume of the hippocampus in brain images may be a reliable way to diagnose Alzheimer's disease.
Giovanni B. Frisoni, M.D. and colleagues are working to develop standard methods to measure the volume of the hippocampus as part of a collaborative effort among two groups of researchers, the European Alzheimer's Disease Consortium (EADC) and the Alzheimer's Disease Neuroimaging Initiative (ADNI). Standardized methods are important because often researchers or clinicians will define the borders of the hippocampus in different ways, thus yielding results that are inconsistent across different clinics or laboratories. In previous research, Dr. Frisoni and colleagues identified different methods in use and began to develop a standard method for defining the borders of the hippocampus. They now plan to obtain consensus among neuroimaging experts regarding the best method to use. The researchers will then validate the chosen method by testing the consistency of its results when used by different researchers. Finally, Dr. Frisoni's team will develop a standard imaging definition of the hippocampus that all researchers and clinicians can use in the future to obtain consistent results. This important effort will advance the use of hippocampal imaging for the diagnosis of Alzheimer's disease, and it will provide a consistent way to measure disease progression and to monitor treatment.