To view an abstract, select an author from the vertical list on the left.
2011 Grants - Lee
Pathogenic Mechanism of Neuronal Cell Cycle Re-entry in Alzheimer's Disease
Hyoung-gon Lee, Ph.D.
Case Western Reserve University
2011 Investigator-Initiated Research Grant
Many cell types reproduce by cell division in an ongoing manner called the cell cycle. In the adult brain, however, nearly all nerve cells have exited the cell cycle, and therefore do not reproduce. If stimulated to re-enter the cell cycle and begin reproducing, most mature nerve cells will die. There is evidence that attempted re-entry into the cell cycle precedes the death of nerve cells in Alzheimer's disease. What causes the cells to re-enter the cell cycle is unknown.
Hyuong-gon Lee, Ph.D. and colleagues have proposed to study the link between re-entry of nerve cells into the cell cycle and beta-amyloid. Beta-amyloid is a protein fragment implicated in Alzheimer's disease and is known to be toxic to nerve cells. Dr. Lee and colleagues seek to determine whether beta-amyloid causes nerve cells to re-enter the cell cycle. They also plan to examine the molecular mechanisms by which this occurs, leading to cell death. For these studies, the researchers will use brain cells from a region of the mouse brain known as the hippocampus, which is especially vulnerable to cell death in Alzheimer's disease. These studies may provide new insights into the molecular mechanisms of an early step in the development of Alzheimer's pathology, and may suggest new targets for treatments to prevent neurodegeneration.