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Research Grants 2005

To view an abstract, select an author from the vertical list on the left side.

2005 Grant - Kagan

Beta-Amyloid Channel Blockers

Bruce L. Kagan, M.D., Ph.D.
University of California
Los Angeles, California

2005 Investigator-Initiated Research Grant

A neuron has tiny pores, or channels, in its membrane that regulate the flow of ions, or electrically charged chemical particles, into and out of the cell. This activity is a function of the nervous system's communication network.

A key feature of Alzheimer's disease is the accumulation of a tiny protein fragment called beta-amyloid. Although there is much evidence that beta-amyloid is a key toxic factor in the disease, its mechanism of action is not well understood. One hypothesis suggests that beta-amyloid creates abnormal ion channels in the membrane of neurons. This "unregulated leaking" of ions would alter the properties and function of a cell.

Bruce L. Kagan, M.D., Ph.D., and colleagues are using a technology that enables the rapid screening of compounds for their ability to block beta-amyloid ion channels. They aim to screen drugs already approved by the Food and Drug Administration and other compounds for their channel-blocking potential. The investigators will assess the effect of the most promising compounds in rats with beta-amyloid–induced brain dysfunction. The outcome of this work may demonstrate the utility of such compounds to block amyloid toxicity and lay the groundwork for future clinical studies.

Alzheimer's Association International Conference | July 16-20, 2017, London, England

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