Alzheimer's Assocation Research only
All of
  • Go to
  • Research Center
  • AAIC
  • Journal
  • Grants
  • TrialMatch
  • Press
  • Donate
  • Contact Us
Science and Progress
Clinical Trials
Funding and Collaboration
You can Help
Stay Current
Video and Resources

Text Size

Small text Medium text Large text

Research Grants 2006

To view an abstract, select an author from the vertical list on the left.

2006 Grant - Liebman

Modeling Alzheimer's Disease in Yeast

Susan W. Liebman, Ph.D.
University of Illinois
Chicago, Illinois

2006 Investigator-Initiated Research Grant

Beta-amyloid is a protein fragment that may be a key factor in damaging cell-to-cell communication and causing the loss of brain cells in Alzheimer's disease. Beta-amyloid molecules assemble themselves into small aggregates, which, in turn, form larger and larger aggregates, eventually forming amyloid plaque. Recent research has indicated that very small aggregates of beta-amyloid-some of the earliest stages of aggregation-may prove to be the main toxic factor in Alzheimer's.

Susan W. Liebman, Ph.D., and colleagues will use genetically altered yeast to study small beta-amyloid aggregates. In these cells, the researchers have fused beta-amyloid to a yeast protein called a reporter protein. If beta-amyloid molecules do not form aggregates, the reporter protein is fully active, enabling the yeast cells to grow and multiply. If beta-amyloid molecules aggregate, the reporter protein is not fully active, resulting in stunted cell growth.

The researchers will use this yeast model to screen a large number of small molecules that may be able to block beta-amyloid aggregation. Cell growth will indicate that a test molecule is blocking aggregation; stunted growth will indicate that the test molecule is not working. This strategy should enable the investigators to identify candidate molecules that can be studied further as potential disease-modifying treatments of Alzheimer's disease.

Alzheimer's Association International Conference | July 16-20, 2017, London, England

Abstract Submissions Now Open

The Scientific Program Committee is now accepting submissions for poster
presentations, oral presentations and featured research sessions.