Alzheimer's Assocation Research only
All of
  • Go to
  • Research Center
  • AAIC
  • Journal
  • Grants
  • TrialMatch
  • Press
  • Donate
  • Contact Us
Science and Progress
Clinical Trials
Funding and Collaboration
You can Help
Stay Current
Video and Resources

Text Size

Small text Medium text Large text

Research Grants 2011

To view an abstract, select an author from the vertical list on the left.

2011 Grants - Yu

Models, Imaging and Drugs for TDP-43 Pathobiology

Gang Yu, Ph.D.
University of Texas Southwestern Medical Center
Dallas, Texas

2011 Investigator-Initiated Research Grant

TDP-43 is a protein with numerous functions within cells. Altered forms of TDP-43 have been implicated in several neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia. Evidence for abnormal TDP-43 has also been found in cases of Alzheimer's disease and Parkinson's disease.

Gang Yu, Ph.D. and colleagues have been studying the functional roles of TDP-43. They have proposed to develop a strain of mice genetically modified to have a version of TDP-43 that can be visualized with a microscope. To achieve this, the researchers will use molecular biology techniques to change the TDP-43 gene so that the final protein contains specialized regions that fluoresce when exposed to light of a certain wavelength. They have already shown the ability to do this without affecting the function of TDP-43.

Using mice carrying the gene for fluorescent TDP-43, Dr. Yu and colleagues will determine where the protein is localized, how it aggregates, and how it is transported within cells. Finally, the researchers will use cells containing fluorescent TDP-43 to identify drug candidates that alter its properties. These studies will provide new insights into the function of TDP-43 and its role in disease, and they may help to identify potential new therapies for inhibiting some forms of neurodegeneration.

Alzheimer's Association International Conference | July 16-20, 2017, London, England

Abstract Submissions Now Open

The Scientific Program Committee is now accepting submissions for poster
presentations, oral presentations and featured research sessions.