Finding a way to slow the progression, effectively prevent and ultimately cure Alzheimer's disease is one of the greatest healthcare challenges of our time. An estimated 55 million people are living with Alzheimer's and dementia worldwide — a number that can only be changed for future generations through research.
Part the Cloud is committed to funding novel research ideas to determine if they will be effective treatments for the millions of people affected by Alzheimer's.
While the vast increase in our understanding of Alzheimer's has led to the identification of promising targets for new therapies, the process of developing and testing potential therapies is long and complex, taking years and substantial resources. Many promising research ideas stall due to lack of funding.
Most grants support middle and latter clinical trials, but there are few funding sources to support the earlier phase studies needed to test drug treatments in people. Part the Cloud addresses this critical gap, supporting early phase clinical studies and helping accelerate the transition of findings from the laboratory into possible therapies.
Part the Cloud has generated more than $85 million in funding for Alzheimer's research, making it possible for the Alzheimer's Association to award 68 additional research grants during this time. These awards span a variety of targets in Alzheimer's disease research and fall under the leadership of some of the nation's most prestigious scientists and universities.
Our Mission: To fund Alzheimer's research with the highest probability of slowing, stopping or ultimately curing Alzheimer's disease.
donatePart the Cloud offers two types of grants, the Translational Research Grant Program and Challenges.
The Translational Research Grant Program focuses on the most exciting science in the dementia field that is ready for early trials. These grants are awarded annually. Research areas include metabolic function; cell signaling and communication; cell senescence; immune response, misfolded proteins and growth factors; amyloid and tau related; vascular and oxidative stress related; and genome sequencing.
Challenges focus on a specific topic and are awarded biennially.
Part the Cloud’s newest fundraising initiative — the Gene Targeting Challenge — will supercharge the development of therapies tailored to the genetic underpinnings of Alzheimer’s disease by supporting new and ongoing early-stage clinical trials using gene targeting. Applications are closed and funding announcements will be made in spring 2025.
Bill Gates joined the Alzheimer's Association Part the Cloud Grant Program in a shared vision for innovation by making a $10 million award. The Alzheimer's Association worked through Part the Cloud to raise $20 million, doubling the total clinical research investment to over $60 million. This partnership will help propel 19 high-risk, high-reward research projects aimed at potential new treatments and devices for Alzheimer's and dementia. From 128 ideas submitted from 18 countries, over $30 million was awarded to 19 researchers to further develop their proposals over 3 years.
The Part the Cloud to RESCUE (REverse, reStore, Cease and UndErstand) Brain Cell Degeneration in Alzheimer's disease challenge aims to accelerate the discovery and testing of innovative compounds to be used for interventions in the earliest stages of neurodegeneration-dementia-Alzheimer’s disease. Presently, there are no effective interventions to delay or prevent the progression of the neurodegenerative processes that underlie the disabling symptoms of Alzheimer's dementia. From 45 proposals submitted from two countries, six researchers were awarded $1 million each to develop their proposals over two years.
A first-of-its-kind competition, the Part the Cloud Neuroinflammation Challenge was created to accelerate therapeutics and deepen understanding of neurodegeneration to be used in early clinical trials. Scientists around the world were invited to submit proposals that could translate into human trials of treatments targeting neuroinflammation with the goal of improving cognition in individuals with neurodegenerative diseases.
From 60 proposals submitted from 14 countries, four researchers were awarded $1 million each to develop their proposals over a two-year period. After two years, projects were evaluated, and the most outstanding project was awarded an additional $3 million to take it and the field to the next level.
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