2023 Strategic Grant (SG)
Immune cells regulate tau pathology and tau-mediated neurodegeneration
Xiaoying Chen, Ph.D.
Washington University, School of Medicine
Saint Louis, MO - United States
The Blas Frangione Early Career Achievement Award recognizes early career researchers whose cutting edge research in Alzheimer’s and dementia has the potential to impact the field by propelling it in novel directions. It also recognizes a researcher’s demonstrated personal and professional qualities that show promise for a productive and impactful scientific career in the Alzheimer’s and dementia field. The Blas Frangione Award was established by and named for Blas Frangione, M.D., Ph.D., who is Professor Emeritus of Pathology and Psychiatry and Research Professor in the Departments of Pathology and Neurology at NYU Langone Medical Center. The Blas Frangione Foundation supports research in neuroscience.Xiaoying Chen, Ph.D., is the 2023 recipient of the Blas Frangione Early Career Achievement Award. This award recognizes early career researchers whose cutting edge research in Alzheimer’s and dementia has the potential to impact the field by propelling it in novel directions. Chen is a faculty member in the Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center at Washington University in St. Louis, School of Medicine. Chen has made key conceptual advances in our knowledge of Alzheimer’s disease, including demonstrating that the adaptive immune response is involved in tau-mediated neurodegeneration. Her work has answered key questions about how tau aggregation leads to regional neuronal death and dementia. Her honors include the O’Leary Prize for Best Neuroscience Research at Washington University in St. Louis, the Poletsky Award for Alzheimer’s Disease Research from Washington University in St. Louis, the Tau Consortium Fellowship from Rainwater Charitable Foundation, the Coins for Alzheimer’s Research Trust from Rotary Foundation, the Career Development Award from Society for Neuroscience.