Find a U.S. POINTER Location

Progress in Alzheimer's and dementia research depends on clinical trials, and eligible participants are needed to move this vital research forward. By participating in U.S. POINTER, you can help to broaden our understanding of risk reduction of cognitive decline.

A wide variety of volunteers, in particular those of diverse backgrounds and under-represented populations, is essential to exploring new approaches and strategies to advance Alzheimer’s research and address scientific gaps.

Key Eligibility for U.S. POINTER

  • People between the ages of 60 and 79
  • People who are not regular exercisers (generally less than 3 times per week)
  • People who may have other risks for memory loss in the future such as family history of memory problems or slightly high blood pressure, cholesterol or blood sugar.
  • Live within an area where the study is being conducted
  • Additional criteria evaluated at screening

Not eligible for this study? Learn about other Clinical Trials.

Apply at One of These Locations

Advocate Health Care

Chicago, Illinois
Phone: 1.847.720.6467

Learn More and Apply

Baylor College of Medicine

Houston, Texas
Phone: 1.713.798.5452

Learn More and Apply

Butler Hospital

Providence, Rhode Island
Phone: 1.401.455.6402

Learn More and Apply


Rush University Medical Center

Chicago, Illinois
Phone: 1.708.660.6463

Learn More and Apply

UC Davis School of Medicine

Sacramento, California
Phone: 1.916.734.0121

Learn More and Apply

Wake Forest School of Medicine

Winston-Salem, North Carolina
Phone: 1.833.361.7591

Learn More and Apply


Add-On Studies

U.S. POINTER add-on studies look deeper into the science of the main study. The neuroimaging ancillary study is the first large-scale investigation of how lifestyle interventions affect biological changes in the brain associated with Alzheimer's and dementia. The sleep ancillary study will examine whether changes in sleep predict changes in overall cognitive function or in specific areas, such as memory.

The U.S. POINTER Neuroimaging Ancillary Study
The U.S. POINTER-zzz Sleep Study
The POINTER-Microbiome Study
The U.S. POINTER NeuroVascular Study: POINTER-NV

Other Clinical Trial Opportunities

Contributing to progress in Alzheimer’s research is a highly valuable contribution to a better future for all. If you are not a potential fit for U.S. POINTER or do not live near a U.S. POINTER study site, there are many other important clinical trials underway that need participants.

Learn about studies that are currently recruiting participants by visiting and completing a TrialMatch profile online or call 1.800.272.3900 (press 1 for clinical trials). Completing a TrialMatch profile does not commit you to participating in a study.

Get U.S. POINTER Information

Whether you are a researcher or potential participant, use this contact information to receive answers to your questions regarding U.S. POINTER.

Phone: 800.272.3900

Find a Location
Who We Are