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Progress in Alzheimer's and dementia research depends on clinical studies and eligible participants are needed to move this vital research forward.

Key Eligibility for U.S. POINTER

- 60 to 79 years of age
- Not a regular exerciser (generally less than three times per week)
- No current memory or thinking problems
- First degree family history of significant memory problems (mother, father, sibling)
- Live within an area where the study is being conducted
- Additional criteria evaluated at screening

Not eligible for this study? Learn about other Clinical Trials.

Study Locations

Wake Forest School of Medicine

Winston-Salem, North Carolina
Co-Principal Investigators:
Jeff Williamson, M.D. and Maryjo Cleveland, M.D.
Recruitment information:
Phone: 1.833.361.7591

UC Davis School of Medicine

Sacramento, California
Co-Principal Investigators:
Rachel Whitmer, Ph.D. and Sarah Farias, Ph.D.
Recruiting information:
Phone: 1.916.734.0121

Rush University Medical Center

Chicago, Illinois
Principal Investigator:
Martha Clare Morris
Recruiting information:
Phone: 1.708.660.6463


Add-On Studies

U.S. POINTER add-on studies look deeper into the science of the main study. The neuroimaging ancillary study is the first large-scale investigation of how lifestyle interventions affect biological changes in the brain associated with Alzheimer's and dementia. The sleep ancillary study will examine whether changes in sleep predict changes in overall cognitive function or in specific areas, such as memory.

The U.S. POINTER Neuroimaging Ancillary Study
The U.S. POINTER-zzz Sleep Study

Other Clinical Trial Opportunities

Contributing to progress in Alzheimer’s research is a highly valuable contribution to a better future for all. If you are not a potential fit for U.S. POINTER or do not live near a U.S. POINTER study site, there are many other important clinical trials underway that need participants.

Learn about studies that are currently recruiting participants by visiting and completing a TrialMatch profile online or call 1.800.272.3900 (press 1 for clinical trials). Completing a TrialMatch profile does not commit you to participating in a study.

Get U.S. POINTER Information

Whether you are a researcher or potential participant, use this contact information to receive answers to your questions regarding U.S. POINTER.

Phone: 800.272.3900

Get Involved
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