U.S. POINTER is no longer recruiting participants as of March 1, 2023. If you are interested in learning more about participating in other Alzheimer's and memory loss studies, visit TrialMatch to be connected to the latest opportunities.

The Alzheimer's Association U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a two-year clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at increased risk for cognitive decline. U.S. POINTER is the first such study to be conducted in a large group of Americans across the United States.

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Who We Are

Read about U.S. POINTER study leadership and our principal investigators.

Meet the Leaders

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Study Overview

Find out about the largest multidomain lifestyle intervention trial for the prevention of Alzheimer's.

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Alzheimer's Resources

Browse helpful Alzheimer's disease information.

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A Global Effort

In 2014, a large-scale two-year study in Finland in healthy older adults at increased risk of cognitive decline and dementia (the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, or FINGER Study) reported that a two-year combination therapy simultaneously targeting physical exercise, a healthy diet, cognitive stimulation, and self-monitoring of heart health risk factors had a protective effect on cognitive function. FINGER and U.S. POINTER join other similar efforts around the globe in a worldwide consortium, World Wide FINGERS (WW-FINGERS). WW-FINGERS will align these research efforts focused on the prevention of Alzheimer's disease and other dementias across the globe.

Study Overview
Who We Are

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